Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

3-Chloro-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)aniline

  • CAS No. 72045-93-3

  • Cat. No. CS-0455158
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Chloro-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)aniline|CS-0455158

Structure of 72045-93-3

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 72045-93-3
  • Cat. No. CS-0455158
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₈ClF₃N₂O
  • Molecular Weight 288.65
  • Synonym(s) 3-Chloro-4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}aniline
  • SMILES C1=CC(=NC=C1C(F)(F)F)OC2=C(C=C(C=C2)N)Cl

Description

This trifluoromethyl-substituted aniline integrates a chlorinated aryl ring with a pyridine-oxide linkage, delivering enhanced electron-withdrawing character and improved metabolic stability. The ortho-chloro group enables selective coupling reactions, while the para-trifluoromethylpyridin-2-yl ether moiety imparts high lipophilicity and resistance to oxidative degradation, making it valuable for medicinal chemistry applications requiring robust scaffold integrity under physiological conditions.

Application

3-Chloro-4-((5-(trifluoromethyl)pyridin-2-yl)oxy)aniline serves as a versatile building block for pharmaceutical intermediates, enabling direct coupling in Suzuki-Miyaura and Buchwald-Hartwig reactions. The chloro group facilitates palladium-catalyzed cross-coupling, while the pyridine-N and aniline functionalities offer orthogonal reactivity. Bench-stable and compatible with standard purification methods, it supports efficient synthesis of complex heterocyclic scaffolds relevant to kinase inhibitors and targeted therapeutics.

Synthesis

  • Route1

    References

    • Okada; Koyanagi; Yamada; Haga Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 9 p. 2308 - 2315

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302+H312+H332-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P362-P363-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   48.14
  • LogP   4.1283
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 72045-93-3 sigma72045-93-3 manufacturer72045-93-3 price72045-93-3 structure72045-93-3 SDSbuy 72045-93-372045-93-3 supplier72045-93-3 uses72045-93-3 molecular weightprice of 72045-93-372045-93-3 chemical name formula of 72045-93-3
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label