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CS-W001157 4
Total: USD 88.00

5-Iodo-1-methyl-1H-imidazole

  • CAS No. 71759-88-1

  • Cat. No. CS-W006750
  • Purity≥95%
  • MDL No.MFCD01632215

*For research and further manufacturing use only, not for direct human use.

5-Iodo-1-methyl-1H-imidazole|CS-W006750

Structure of 71759-88-1

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General Information

  • CAS No. 71759-88-1
  • Cat. No. CS-W006750
  • Purity ≥95%
  • MDL No. MFCD01632215
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅IN₂
  • Molecular Weight 208.00
  • Synonym(s) 5-Iodo-1-methylimidazole
  • SMILES CN1C(I)=CN=C1

Description

5-Iodo-1-methyl-1H-imidazole features a reactive iodine handle at the 5-position, enabling efficient coupling in cross-coupling and bioconjugation workflows. The methyl group enhances solubility and stability, while the imidazole core provides a robust heterocyclic scaffold for medicinal chemistry applications.

Application

5-Iodo-1-methyl-1H-imidazole serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling direct C–H functionalization and cross-coupling reactions. Its iodine substituent facilitates palladium-catalyzed transformations with high efficiency, while the N-methyl group enhances solubility and stability. The imidazole core provides orthogonal reactivity for further derivatization, making it a practical scaffold for heterocyclic compound development.

Synthesis

  • Route1
    • 2,5-Diiodo-1-methylimidazole|CS-0053920
      86026-81-5
    • ~87%
    • In-stock
      5-Iodo-1-methyl-1H-imidazole|CS-W006750
      71759-88-1

    References

    • Borai, M. El; Moustafa, A. H.; Anwar, M.; Hay, F. I. Abdel Polish Journal of Chemistry, 1981 , vol. 55, # 7/8 p. 1659 - 1665
  • Route2

    References

    • Holden, Kenneth G; Mattson, Matthew N; Cha, Kyung Hoi; Rapoport, Henry The Journal of organic chemistry, 2002 , vol. 67, # 17 p. 5913 - 5918
  • Route3
    • null|null
      592554-93-3
    • ~%
    • In-stock
      5-Iodo-1-methyl-1H-imidazole|CS-W006750
      71759-88-1

    References

    • US2004/122018 A1, ; Page 403 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H317-H319-H335
Precautionary Statements : P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.82
  • LogP   1.0247
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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