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2-(Chloromethyl)-5-methyl-Pyridine hydrochloride

  • CAS No. 71670-70-7

  • Cat. No. CS-M3234
  • Purity≥98%
  • MDL No.MFCD18253390

*For research and further manufacturing use only, not for direct human use.

2-(Chloromethyl)-5-methyl-Pyridine hydrochloride|CS-M3234

Structure of 71670-70-7

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General Information

  • CAS No. 71670-70-7
  • Cat. No. CS-M3234
  • Purity ≥98%
  • MDL No. MFCD18253390
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₉Cl₂N
  • Molecular Weight 178.06
  • Synonym(s) 2-(Chloromethyl)-5-methylpyridine hydrochloride
  • SMILES CC1=CN=C(CCl)C=C1.Cl

Description

2-(Chloromethyl)-5-methyl-Pyridine hydrochloride features a chloromethyl group at the 2-position of a pyridine ring bearing a methyl substituent at the 5-position. This electron-deficient heterocycle enables selective alkylation reactions under mild conditions, offering enhanced reactivity in synthetic transformations. The hydrochloride salt ensures improved solubility and stability for handling in aqueous or polar organic media.

Application

2-(Chloromethyl)-5-methyl-pyridine hydrochloride serves as a versatile building block for the synthesis of pharmaceutical intermediates and functionalized heterocycles. The chloromethyl group enables efficient nucleophilic substitution, while the pyridine nitrogen provides a handle for metal coordination or derivatization. Its bench-stable hydrochloride salt form enhances handling and purification, offering good functional group tolerance in standard coupling and alkylation workflows.

Synthesis

  • Route1

    References

    • RANBAXY LABORATORIES LIMITED Patent: WO2006/117754 A1, 2006 ; Location in patent: Page/Page column 24 ; WO 2006/117754 A1
  • Route2
    • In-stock
      (5-Methylpyridin-2-yl)methanol|CS-0014708
      22940-71-2
    • null|null
      7719-09-7
    • ~%
    • In-stock
      2-(Chloromethyl)-5-methyl-Pyridine hydrochloride|CS-M3234
      71670-70-7

    References

    • RANBAXY LABORATORIES LIMITED Patent: WO2004/52857 A1, 2004 ; Location in patent: Page 61 ; WO 2004/052857 A1
  • Route3

    References

    • Hoffmann-La Roche Inc. Patent: US4182766 A1, 1980 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.55062
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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