Lot numbers can be found on the outside label of a product:
6-Chloro-4-methoxy Nicotinic Acid
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CAS No. 716362-10-6
- Cat. No. CS-W003725
- Purity≥98%
- MDL No.MFCD10000638
*For research and further manufacturing use only, not for direct human use.
Structure of 716362-10-6
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General Information
- CAS No. 716362-10-6
- Cat. No. CS-W003725
- Purity ≥98%
- MDL No. MFCD10000638
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₆ClNO₃
- Molecular Weight 187.58
- Synonym(s) 6-Chloro-4-methoxynicotinic acid
- SMILES OC(C1=CN=C(Cl)C=C1OC)=O
Description
6-Chloro-4-methoxy nicotinic acid is a bench-stable, electron-deficient pyridine derivative featuring a chloro group at the 6-position and a methoxy substituent at the 4-position. This combination enhances regioselectivity in cross-coupling reactions and improves solubility in polar organic solvents. The compound serves as a key building block for pharmaceutical intermediates and bioactive heterocycles.
Application
6-Chloro-4-methoxy nicotinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of substituted pyridine scaffolds through standard coupling and cyclization reactions. Its orthogonal functional groups—chlorine at C6 and methoxy at C4—facilitate selective derivatization, while its bench-stable crystalline form simplifies handling and purification. This compound functions effectively in Suzuki-Miyaura and Buchwald-Hartwig cross-coupling protocols, supporting efficient access to bioactive heterocycles and API intermediates.
Synthesis
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Route1
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67-56-1 -
In-stock
73027-79-9 - ~70%
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In-stock
716362-10-6
References
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BRISTOL-MYERS SQUIBB COMPANY; MOSLIN, Ryan M.; LIN, Shuqun; WEINSTEIN, David S.; WROBLESKI, Stephen T.; ZHANG, Yanlei; TOKARSKI, John S. Patent: WO2014/74660 A1, 2014 ; Location in patent: Paragraph 00163 ;
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Route2
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In-stock
84332-02-5 - ~%
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In-stock
716362-10-6
References
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WO2012/110860 A1, ; Page/Page column 99 ; WO 2012/110860 A1
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Route3
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In-stock
1830-54-2 - ~%
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In-stock
716362-10-6
References
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WO2012/110860 A1, ; WO 2012/110860 A1
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 59.42
- LogP 1.4418
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 2
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Key Words
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