Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

2-Fluoro-6-nitrobenzoic acid

  • CAS No. 385-02-4

  • Cat. No. CS-W002848
  • Purity≥98%
  • MDL No.MFCD01862079

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-6-nitrobenzoic acid|CS-W002848

Structure of 385-02-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 385-02-4
  • Cat. No. CS-W002848
  • Purity ≥98%
  • MDL No. MFCD01862079
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₄FNO₄
  • Molecular Weight 185.11
  • Synonym(s) 2-Carboxy-3-fluoronitrobenzene
  • SMILES [O-][N+](=O)c1cccc(c1C(=O)O)F

Description

2-Fluoro-6-nitrobenzoic acid features a fluorine atom at the ortho position and a nitro group at the para position relative to the carboxylic acid, creating a strongly electron-deficient aromatic ring. This combination enhances reactivity in coupling reactions and improves solubility in polar solvents. The compound serves as a key intermediate in pharmaceutical synthesis, particularly for bioactive heterocycles and targeted drug candidates requiring halogenated or nitro-substituted scaffolds.

Application

2-Fluoro-6-nitrobenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation of fluorinated aromatic systems with orthogonal nitro and carboxylic acid functionalities. Its bench-stable nature and compatibility with standard coupling reactions facilitate efficient derivatization via amide, ester, or amidation protocols. The electron-withdrawing nitro group enhances electrophilicity at the ortho position, supporting subsequent nucleophilic aromatic substitution or transition-metal-catalyzed functionalizations.

Synthesis

  • Route1

    References

    • Bentov,M. et al. Israel Journal of Chemistry, 1964 , vol. 2, p. 25 - 28
  • Route2
    • (2-Fluoro-6-nitrophenyl)methanol|CS-0380069
      1643-60-3
    • ~%
    • In-stock
      2-Fluoro-6-nitrobenzoic acid|CS-W002848
      385-02-4

    References

    • Bentov,M. et al. Israel Journal of Chemistry, 1964 , vol. 2, p. 25 - 28
  • Route3

    References

    • Bentov,M. et al. Israel Journal of Chemistry, 1964 , vol. 2, p. 25 - 28

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   80.44
  • LogP   1.4321
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • 2-Fluoro-6-nitrobenzoic acid sigma2-Fluoro-6-nitrobenzoic acid manufacturer2-Fluoro-6-nitrobenzoic acid price2-Fluoro-6-nitrobenzoic acid structure2-Fluoro-6-nitrobenzoic acid SDSbuy 2-Fluoro-6-nitrobenzoic acid2-Fluoro-6-nitrobenzoic acid supplier2-Fluoro-6-nitrobenzoic acid uses2-Fluoro-6-nitrobenzoic acid molecular weightprice of 2-Fluoro-6-nitrobenzoic acid2-Fluoro-6-nitrobenzoic acid chemical name formula of 2-Fluoro-6-nitrobenzoic acid
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label