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CS-W001157 4
Total: USD 88.00

3,5-Diiodopyridin-4-ol

  • CAS No. 7153-08-4

  • Cat. No. CS-0092729
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3,5-Diiodopyridin-4-ol|CS-0092729

Structure of 7153-08-4

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General Information

  • CAS No. 7153-08-4
  • Cat. No. CS-0092729
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃I₂NO
  • Molecular Weight 346.89
  • Synonym(s) 4-Hydroxy-3,5-diiodopyridine
  • SMILES OC1=C(I)C=NC=C1I

Description

3,5-Diiodopyridin-4-ol features two iodine atoms positioned at the 3 and 5 ring positions, flanking a hydroxyl group at C4. This electron-deficient pyridinol scaffold enables direct functionalization in cross-coupling reactions, offering high reactivity under palladium catalysis. The molecule exhibits excellent stability under standard bench conditions, facilitating straightforward handling in synthetic workflows.

Application

3,5-Diiodopyridin-4-ol serves as a versatile building block for the synthesis of functionalized heterocycles, enabling palladium-catalyzed cross-coupling reactions with high efficiency. Its iodinated pyridinol framework exhibits excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures. This compound functions as a key intermediate in the construction of bioactive scaffolds and advanced pharmaceutical candidates.

Synthesis

  • Route1

    References

    • Rousseau, Gerard; Robin, Sylvie Tetrahedron Letters, 1997 , vol. 38, # 14 p. 2467 - 2470
  • Route2
    • Pyridin-4(1H)-one|CS-0166783
      108-96-3
    • ~%
    • In-stock
      3,5-Diiodopyridin-4-ol|CS-0092729
      7153-08-4

    References

    • I.G.Farbenind. Patent: ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 20, p. 765
  • Route3

    References

    • Pfanz; Dorn Archiv der Pharmazie (Weinheim, Germany), 1956 , vol. 289, p. 651,660

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   1.9964
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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