Lot numbers can be found on the outside label of a product:
4-Chloro-3-methylaniline
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CAS No. 7149-75-9
- Cat. No. CS-W002307
- Purity≥98%
- MDL No.MFCD00066332
*For research and further manufacturing use only, not for direct human use.
Structure of 7149-75-9
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General Information
- CAS No. 7149-75-9
- Cat. No. CS-W002307
- Purity ≥98%
- MDL No. MFCD00066332
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₇H₈ClN
- Molecular Weight 141.60
- Synonym(s) 5-Amino-2-chlorotoluene~4-Chloro-m-toluidine; 4-Chloro-3-methylaniline
- SMILES Nc1ccc(c(c1)C)Cl
Description
4-Chloro-3-methylaniline is a chlorinated aniline derivative featuring a methyl group at the meta position relative to the amino function. This substitution pattern imparts enhanced electron density at the aromatic ring, facilitating electrophilic coupling reactions. The compound exhibits good bench stability and solubility in common organic solvents, enabling straightforward integration into synthetic sequences for pharmaceutical intermediates and agrochemical building blocks.
Application
4-Chloro-3-methylaniline serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of substituted anilines via standard coupling reactions. Its ortho-methyl group enhances metabolic stability and modulates electronic properties, while the chloro substituent provides a handle for palladium-catalyzed functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for scalable, multi-step synthetic sequences.
Synthesis
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Route1
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108-44-1 - ~95%
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In-stock
7149-75-9
References
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Wang, Han; Wen, Kun; Nurahmat, Nurbiya; Shao, Yan; Zhang, He; Wei, Chao; Li, Ya; Shen, Yongjia; Sun, Zhihua Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 744 - 748
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Route2
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In-stock
13290-74-9 - ~%
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In-stock
7149-75-9
References
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Justus Liebigs Annalen der Chemie, , vol. 168, p. 210 Chemische Berichte, , vol. 19, p. 2443 Chemische Berichte, , vol. 20, p. 199 Chemische Berichte, , vol. 20, p. 200
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Route3
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372-19-0
- ~92%
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In-stock
7149-75-9
References
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Wang, Han; Wen, Kun; Nurahmat, Nurbiya; Shao, Yan; Zhang, He; Wei, Chao; Li, Ya; Shen, Yongjia; Sun, Zhihua Beilstein Journal of Organic Chemistry, 2012 , vol. 8, p. 744 - 748
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 26.02
- LogP 2.23062
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 0
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Key Words
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