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CS-W001157 4
Total: USD 88.00

O-Methyl-D-valine hydrochloride

  • CAS No. 7146-15-8

  • Cat. No. CS-0012693
  • Purity≥97%
  • MDL No.MFCD00237309

*For research and further manufacturing use only, not for direct human use.

O-Methyl-D-valine hydrochloride|CS-0012693

Structure of 7146-15-8

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General Information

  • CAS No. 7146-15-8
  • Cat. No. CS-0012693
  • Purity ≥97%
  • MDL No. MFCD00237309
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄ClNO₂
  • Molecular Weight 167.63
  • Synonym(s) Methyl (R)-2-amino-3-methylbutanoate hydrochloride; Methyl D-valinate hydrochloride; NSC 22921
  • SMILES CC(C)[C@@H](N)C(OC)=O.[H]Cl

Description

O-Methyl-D-valine (hydrochloride) is a non-proteinogenic amino acid featuring a methylated hydroxyl group and D-stereochemistry, offering enhanced metabolic stability. This bench-stable derivative integrates readily into peptide sequences, providing improved bioavailability and resistance to enzymatic degradation in therapeutic development workflows.

Application

O-Methyl-D-valine (hydrochloride) serves as a stable, bench-ready building block for peptide synthesis and medicinal chemistry applications. Its methylated hydroxyl group enhances metabolic stability and lipophilicity, while the D-configuration enables incorporation into non-natural peptide scaffolds. The hydrochloride salt improves solubility and handling, facilitating straightforward purification and compatibility with standard coupling protocols in solid-phase and solution-phase synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   0.5645
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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