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(R)-2-((tert-Butoxycarbonyl)amino)-3-chloropropanoic acid

  • CAS No. 71404-98-3

  • Cat. No. CS-0100208
  • Purity≥97%
  • MDL No.MFCD00672318

*For research and further manufacturing use only, not for direct human use.

(R)-2-((tert-Butoxycarbonyl)amino)-3-chloropropanoic acid|CS-0100208

Structure of 71404-98-3

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General Information

  • CAS No. 71404-98-3
  • Cat. No. CS-0100208
  • Purity ≥97%
  • MDL No. MFCD00672318
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄ClNO₄
  • Molecular Weight 223.65
  • Synonym(s) BOC-BETA-CHLORO-ALA-OH
  • SMILES O=C(O)[C@H](CCl)NC(OC(C)(C)C)=O

Description

This chiral building block features a protected (R)-amino acid scaffold with a strategically positioned chloro substituent. The tert-butoxycarbonyl group ensures stability and orthogonal handling, while the β-chloropropionic acid moiety enables downstream functionalization in peptide synthesis and medicinal chemistry applications.

Synthesis

  • Route1

    References

    • Cheung, Kam Sing; Wasserman, Steven A.; Dudek, Edward; Lerner, Stephen A.; Johnston, Michael Journal of Medicinal Chemistry, 1983 , vol. 26, # 12 p. 1733 - 1741
  • Route2

    References

    • University of Florida Patent: US4888427 A1, 1989 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   1.2031
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   3

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