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CS-W001157 4
Total: USD 88.00

5-Chlorosalicylamide

  • CAS No. 7120-43-6

  • Cat. No. CS-W017643
  • Purity≥98%
  • MDL No.MFCD00007980

*For research and further manufacturing use only, not for direct human use.

5-Chlorosalicylamide|CS-W017643

Structure of 7120-43-6

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General Information

  • CAS No. 7120-43-6
  • Cat. No. CS-W017643
  • Purity ≥98%
  • MDL No. MFCD00007980
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆ClNO₂
  • Molecular Weight 171.58
  • Synonym(s) 5-Chloro-2-hydroxybenzamide
  • SMILES ClC1=CC(C(N)=O)=C(O)C=C1

Description

5-Chlorosalicylamide features a chlorinated aromatic ring fused to a salicylamide scaffold, delivering enhanced electron-withdrawing character and improved solubility in polar solvents. This structural configuration supports its use in synthesizing bioactive heterocycles and pharmaceutical intermediates under standard conditions.

Application

5-Chlorosalicylamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxyamide functionality supports efficient cyclization reactions and metal coordination, while the chloro substituent offers moderate electrophilic character for further functionalization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for multi-step synthetic sequences in API development.

Synthesis

  • Route1

    References

    • Kim, Jihye; Kang, Sookjin; Hong, Sungchae; Yum, Soowhan; Kim, Young Mi; Jung, Yunjin European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 36 - 44
  • Route2
    • null|null
      37540-16-2
    • ~%
    • In-stock
      5-Chlorosalicylamide|CS-W017643
      7120-43-6

    References

    • US2003/216593 A1, ; Page/Page column 7-8 ;
  • Route3
    • null|null
      88599-37-5
    • ~64%
    • In-stock
      6-Chloro-2H-benzo[e][1,3]oxazine-2,4(3H)-dione|CS-0138304
      24088-81-1
    • In-stock
      5-Chlorosalicylamide|CS-W017643
      7120-43-6

    References

    • Journal of Organic Chemistry, , vol. 53, # 17 p. 4112 - 4114

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   63.32
  • LogP   1.1445
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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