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CS-W001157 4
Total: USD 88.00

4-Trifluoroacetylanisole

  • CAS No. 711-38-6

  • Cat. No. CS-0028395
  • Purity≥95%
  • MDL No.MFCD00018061

*For research and further manufacturing use only, not for direct human use.

4-Trifluoroacetylanisole|CS-0028395

Structure of 711-38-6

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General Information

  • CAS No. 711-38-6
  • Cat. No. CS-0028395
  • Purity ≥95%
  • MDL No. MFCD00018061
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇F₃O₂
  • Molecular Weight 204.15
  • Synonym(s) NSC 55522; 4'-Methoxy-2,2,2-trifluoroacetophenone 4-(Trifluoroacetyl)anisole
  • SMILES FC(F)(F)C(C1=CC=C(OC)C=C1)=O

Description

4-Trifluoroacetylanisole features a para-trifluoroacetyl group appended to an aromatic ring, delivering enhanced electron-withdrawing character and improved metabolic stability. This trifluoromethylated aryl ketone integrates readily into synthetic sequences requiring polar, sterically accessible functional handles. The molecule exhibits robust bench stability and compatibility with standard reaction conditions in medicinal chemistry workflows.

Application

4-Trifluoroacetylanisole serves as a versatile building block in medicinal chemistry, enabling efficient access to trifluoromethylated aryl scaffolds. Its stability under standard reaction conditions and compatibility with palladium-catalyzed cross-coupling reactions facilitate the construction of complex biaryl architectures. The trifluoroacetyl group provides enhanced metabolic stability and modulates electronic properties, making it valuable for lead optimization in pharmaceutical development.

Synthesis

  • Route1
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      502607-05-8
    • ~%
    • In-stock
      4-Trifluoroacetylanisole|CS-0028395
      711-38-6

    References

    • Tetrahedron, , vol. 58, # 42 p. 8565 - 8571
  • Route2
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      100-07-2
    • ~%
    • In-stock
      4-Trifluoroacetylanisole|CS-0028395
      711-38-6

    References

    • Chemical Communications, , vol. 48, # 77 p. 9610 - 9612
  • Route3
    • null|null
      100-66-3
    • ~%
    • In-stock
      4-Trifluoroacetylanisole|CS-0028395
      711-38-6

    References

    • Chemistry - A European Journal, , vol. 19, # 21 p. 6551 - 6555

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.4402
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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