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CS-W001157 4
Total: USD 88.00

1-Methoxy-4-(trifluoromethoxy)benzene

  • CAS No. 710-18-9

  • Cat. No. CS-0081133
  • Purity≥98%
  • MDL No.MFCD00216942

*For research and further manufacturing use only, not for direct human use.

1-Methoxy-4-(trifluoromethoxy)benzene|CS-0081133

Structure of 710-18-9

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General Information

  • CAS No. 710-18-9
  • Cat. No. CS-0081133
  • Purity ≥98%
  • MDL No. MFCD00216942
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇F₃O₂
  • Molecular Weight 192.14
  • Synonym(s) 4-(Trifluoromethoxy)anisole
  • SMILES FC(F)(F)OC(C=C1)=CC=C1OC

Description

1-Methoxy-4-(trifluoromethoxy)benzene features a para-substituted aromatic ring with complementary electron-donating and electron-withdrawing groups, enabling robust participation in cross-coupling reactions. The trifluoromethoxy moiety imparts enhanced metabolic stability and lipophilicity, while the methoxy group provides a reliable handle for further functionalization under standard conditions.

Application

1-Methoxy-4-(trifluoromethoxy)benzene serves as a versatile aryl building block in medicinal chemistry and materials science, enabling efficient functionalization via Suzuki-Miyaura and Ullmann coupling reactions. Its dual electron-withdrawing trifluoromethoxy and electron-donating methoxy groups provide balanced reactivity and enhanced metabolic stability. The compound exhibits excellent bench stability, simple purification by column chromatography, and compatibility with a broad range of synthetic transformations.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H302+H312+H332-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.5938
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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