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CS-W001157 4
Total: USD 88.00

2-Amino-5-bromonicotinonitrile

  • CAS No. 709652-82-4

  • Cat. No. CS-W015659
  • Purity≥95%
  • MDL No.MFCD08688591
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    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

2-Amino-5-bromonicotinonitrile|CS-W015659

Structure of 709652-82-4

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Description

2-Amino-5-bromonicotinonitrile features a brominated pyridine core with complementary amino and nitrile functionalities, enabling direct incorporation into diverse heterocyclic scaffolds. The electron-deficient ring facilitates cross-coupling reactions, while the amine group offers a handle for derivatization under mild conditions. This compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active molecules.

Application

2-Amino-5-bromonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds via standard coupling and cyclization reactions. Its bromo and nitrile functionalities offer orthogonal reactivity for palladium-catalyzed cross-couplings and hydrolysis to carboxylic acids, respectively. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

General Information

  • CAS No. 709652-82-4
  • Cat. No. CS-W015659
  • Purity ≥95%
  • MDL No. MFCD08688591
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrN₃
  • Molecular Weight 198.02
  • Synonym(s) 5-Bromo-3-cyanopyridin-2-amine
  • SMILES N#CC1=C(N)N=CC(Br)=C1

Computational Chemistry Data

  • TPSA   62.7
  • LogP   1.29798
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group :
Hazard Statements : H301-H315-H318-H335
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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