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Structure of 709652-82-4
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2-Amino-5-bromonicotinonitrile features a brominated pyridine core with complementary amino and nitrile functionalities, enabling direct incorporation into diverse heterocyclic scaffolds. The electron-deficient ring facilitates cross-coupling reactions, while the amine group offers a handle for derivatization under mild conditions. This compound serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and CNS-active molecules.
2-Amino-5-bromonicotinonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds via standard coupling and cyclization reactions. Its bromo and nitrile functionalities offer orthogonal reactivity for palladium-catalyzed cross-couplings and hydrolysis to carboxylic acids, respectively. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.
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GHS Pictogram :
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GHS No : GHS05,GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H318-H335
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Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501
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Lot numbers can be found on the outside label of a product: