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CS-W001157 4
Total: USD 88.00

4-(Hydroxymethyl)-1H-indazole

  • CAS No. 709608-85-5

  • Cat. No. CS-W003762
  • Purity≥98%
  • MDL No.MFCD11052642

*For research and further manufacturing use only, not for direct human use.

4-(Hydroxymethyl)-1H-indazole|CS-W003762

Structure of 709608-85-5

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General Information

  • CAS No. 709608-85-5
  • Cat. No. CS-W003762
  • Purity ≥98%
  • MDL No. MFCD11052642
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 4-Hydroxymethyl-1H-indazole
  • SMILES OCc1cccc2c1cn[nH]2

Description

4-(Hydroxymethyl)-1H-indazole features a reactive hydroxymethyl group positioned at the 4-position of the indazole scaffold, enabling direct functionalization in synthetic transformations. This bench-stable heterocycle integrates readily into bioconjugation strategies and serves as a key intermediate for pharmaceutical development.

Application

4-(Hydroxymethyl)-1H-indazole serves as a versatile building block for medicinal chemistry and heterocyclic synthesis, enabling straightforward functionalization at the C4 position. The hydroxymethyl group facilitates oxidation to carboxylic acid, reduction to methyl, or conversion to other polar functionalities, supporting diverse downstream derivatization. Its stability under standard reaction conditions and compatibility with common protecting group strategies make it well-suited for multi-step synthesis workflows in API development.

Synthesis

  • Route1

    References

    • CHEMOCENTRYX, INC. Patent: WO2007/51062 A2, 2007 ; Location in patent: Page/Page column 126-127 ; WO 2007/051062 A2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   48.91
  • LogP   1.0552
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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