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CS-W001157 4
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Methyl 2-chloroacetimidate hydrochloride

  • CAS No. 70737-12-1

  • Cat. No. CS-0150960
  • Purity≥97%
  • MDL No.MFCD16621446

*For research and further manufacturing use only, not for direct human use.

Methyl 2-chloroacetimidate hydrochloride|CS-0150960

Structure of 70737-12-1

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General Information

  • CAS No. 70737-12-1
  • Cat. No. CS-0150960
  • Purity ≥97%
  • MDL No. MFCD16621446
  • Storage -20°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₇Cl₂NO
  • Molecular Weight 144.00
  • Synonym(s) Methyl 2-chloroethanecarboximidate hydrochloride
  • SMILES COC(=N)CCl.Cl

Description

Methyl 2-chloroacetimidate hydrochloride serves as a reactive acylating agent for amine functionalization. This bench-stable derivative features a chloro-imidate moiety that enables efficient coupling under mild conditions. The hydrochloride salt enhances solubility in polar solvents, streamlining incorporation into synthetic workflows involving peptide and heterocyclic scaffold elaboration.

Application

Methyl 2-chloroacetimidate hydrochloride serves as a reliable reagent for the efficient synthesis of N-acyl imidates and related intermediates. Its stability under standard bench conditions enables straightforward handling and purification, while its high reactivity facilitates rapid acylation of alcohols and amines. Functions as a key building block in the construction of heterocyclic scaffolds and peptide mimetics, offering broad functional group tolerance and compatibility with common reaction protocols.

Synthesis

  • Route1
    • null|null
      67-56-1
    • null|null
      107-14-2
    • ~95%
    • In-stock
      Methyl 2-chloroacetimidate hydrochloride|CS-0150960
      70737-12-1

    References

    • Guillemot, Geoffroy; Neuburger, Markus; Pfaltz, Andreas Chemistry - A European Journal, 2007 , vol. 13, # 32 p. 8960 - 8970
  • Route2
    • null|null
      1634-04-4
    • null|null
      107-14-2
    • ~95%
    • In-stock
      Methyl 2-chloroacetimidate hydrochloride|CS-0150960
      70737-12-1

    References

    • Cowden; Wilson; Bishop; Cottrell; Davies; Dolling Tetrahedron Letters, 2000 , vol. 41, # 44 p. 8661 - 8664
  • Route3
    • null|null
      107-14-2
    • ~%
    • In-stock
      Methyl 2-chloroacetimidate hydrochloride|CS-0150960
      70737-12-1

    References

    • Steinkopf; Malinowski Chemische Berichte, 1911 , vol. 44, p. 2903

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.08
  • LogP   1.27067
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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