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CS-W001157 4
Total: USD 88.00

(R)-Dimethyl 2-hydroxysuccinate

  • CAS No. 70681-41-3

  • Cat. No. CS-W016123
  • Purity≥95%
  • MDL No.MFCD00066216

*For research and further manufacturing use only, not for direct human use.

(R)-Dimethyl 2-hydroxysuccinate|CS-W016123

Structure of 70681-41-3

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General Information

  • CAS No. 70681-41-3
  • Cat. No. CS-W016123
  • Purity ≥95%
  • MDL No. MFCD00066216
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₅
  • Molecular Weight 162.14
  • Synonym(s) Dimethyl L-(-)-Malate
  • SMILES COC(C[C@H](C(OC)=O)O)=O

Synthesis

  • Route1
    • null|null
      67-56-1
    • (R)-2-Hydroxysuccinic acid  Cabozantinib Impurity|CS-0167005
      636-61-3
    • ~98%
    • In-stock
      (R)-Dimethyl 2-hydroxysuccinate|CS-W016123
      70681-41-3

    References

    • Kodra, Janos T.; Jorgensen, Anker Steen; Andersen, Birgitte; Behrens, Carsten; Brand, Christian Lehn; Christensen, Inger Thoger; Guldbrandt, Mette; Jeppesen, Claus Bekker; Knudsen, Lotte B.; Madsen, Peter; Nishimura, Erica; Sams, Christian; Sidelmann, Ulla G.; Pedersen, Raymon A.; Lynn, Francis C.; Lau, Jesper Journal of Medicinal Chemistry, 2008 , vol. 51, # 17 p. 5387 - 5396
  • Route2
    • (R)-2-Hydroxysuccinic acid  Cabozantinib Impurity|CS-0167005
      636-61-3
    • null|null
      104-15-4
    • ~86%
    • In-stock
      (R)-Dimethyl 2-hydroxysuccinate|CS-W016123
      70681-41-3

    References

    • VERTEX PHARMACEUTICALS INCORPORATED Patent: WO2007/21982 A2, 2007 ; Location in patent: Page/Page column 67 ;
  • Route3
    • null|null
      67-56-1
    • null|null
      106-48-9
    • ~%
    • null|null
      553-90-2
    • In-stock
      (R)-Dimethyl 2-hydroxysuccinate|CS-W016123
      70681-41-3
    • null|null
      624-48-6
    • In-stock
      Dimethyl malonate|CS-0019394
      108-59-8

    References

    • Journal of Molecular Catalysis A: Chemical, , vol. 371, p. 15 - 20

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅲ
Hazard Statements : H225-H317-H318
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P272-P280-P302+P352-P362+P364-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   72.83
  • LogP   -0.9166
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   3

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