3,5-Dichlorobenzenesulfonyl chloride

Name: 3,5-Dichlorobenzenesulfonyl chloride
Brand: ChemScene
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CAS No. 705-21-5
Cat. No. CS-W012710
Purity≥97%
MDL No.MFCD00051698

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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3,5-Dichlorobenzenesulfonyl chloride|CS-W012710

Structure of 705-21-5

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General Information

CAS No. 705-21-5
Cat. No. CS-W012710
Purity ≥97%
MDL No. MFCD00051698
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₃Cl₃O₂S
Molecular Weight 245.51
Synonym(s) 3,5-DICHLOROBENZENESULPHONYL CHLORIDE; 3,5-Dichlorobenzenesulfonyl chloride
SMILES O=S(C1=CC(Cl)=CC(Cl)=C1)(Cl)=O

Description

3,5-Dichlorobenzenesulfonyl chloride is a bench-stable, moisture-tolerant sulfonylating agent featuring two chlorine substituents at the 3 and 5 positions of the benzene ring. This electron-deficient architecture enhances reactivity toward nucleophiles, enabling efficient sulfonamide formation under mild conditions. The compound integrates readily into synthetic sequences requiring selective sulfonylation, particularly in pharmaceutical intermediates and functional materials.

Application

3,5-Dichlorobenzenesulfonyl chloride serves as a robust sulfonylating agent for the efficient introduction of the 3,5-dichlorobenzenesulfonyl group into amines and alcohols. Its high reactivity and bench stability enable clean, scalable synthesis of sulfonamide and sulfonate derivatives with excellent functional group tolerance. Widely employed in medicinal chemistry and process development, it facilitates the construction of key heterocyclic scaffolds and serves as a valuable building block for API intermediates requiring enhanced metabolic stability and solubility.

Synthesis

Route1
- 137897-99-5
- ~97%
- In-stock
  
  705-21-5
References
- Pu, Yu-Ming; Christesen, Alan; Ku, Yi-Yin Tetrahedron Letters, 2010 , vol. 51, # 2 p. 418 - 421

Safety Information

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GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 1759
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 34.14
LogP 2.9209
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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3,5-Dichlorobenzenesulfonyl chloride

CAS No. 705-21-5

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