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Fmoc-Ser(Allyl)-OH

  • CAS No. 704910-17-8

  • Cat. No. CS-0059704
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-Ser(Allyl)-OH|CS-0059704

Structure of 704910-17-8

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General Information

  • CAS No. 704910-17-8
  • Cat. No. CS-0059704
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₁H₂₁NO₅
  • Molecular Weight 367.40
  • Synonym(s) N-Fmoc-O-allylserine
  • SMILES C([C@@H](NC(=O)OCC1C=2C=CC=CC2C=3C=CC=CC31)COCC=C)(=O)O

Description

Fmoc-Ser(Allyl)-OH is a protected serine derivative featuring an allyl group at the hydroxyl position, enabling orthogonal deprotection in peptide synthesis. The Fmoc moiety provides stable N-terminal protection, while the allyl side chain allows selective removal under mild conditions. This combination facilitates efficient incorporation of serine residues with high fidelity and minimal side reactions.

Application

Fmoc-Ser(Allyl)-OH serves as a valuable building block in peptide synthesis, enabling site-specific incorporation of serine with orthogonal protection. The allyl group provides stable protection under standard Fmoc conditions and can be selectively removed via palladium-catalyzed cleavage, facilitating late-stage functionalization. Its bench-stable nature and compatibility with common coupling reagents make it ideal for both manual and automated synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.86
  • LogP   3.1809
  • H_Acceptors   4
  • H_Donors   2
  • Rotatable_Bonds   8

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