Fmoc-D-Ser(Allyl)-OH

Name: Fmoc-D-Ser(Allyl)-OH
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CAS No. 2381970-72-3
Cat. No. CS-0798562
Molecule weight367.40
Purity≥97%
MDL No.None

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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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General Information

CAS No. 2381970-72-3
Cat. No. CS-0798562
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₁NO₅
Molecular Weight 367.40
Synonym(s) None
SMILES C(OC(N[C@H](COCC=C)C(O)=O)=O)C1C=2C(C=3C1=CC=CC3)=CC=CC2

Description

Fmoc-D-Ser(Allyl)-OH is a protected D-serine derivative featuring a labile allyl group at the side chain, enabling orthogonal deprotection in peptide synthesis. The Fmoc moiety provides efficient N-terminal protection, while the allyl handle offers compatibility with palladium-catalyzed cleavage. This combination streamlines the incorporation of D-Ser residues with minimal side reactions under standard conditions.

Application

Fmoc-D-Ser(Allyl)-OH serves as a key building block in peptide synthesis, enabling the incorporation of D-serine with orthogonal protection. The allyl group provides reliable deprotection under mild palladium catalysis, preserving labile functionalities. The Fmoc group ensures efficient stepwise chain elongation, while the D-configuration offers strategic stereochemical control. This compound facilitates the synthesis of complex peptidomimetics and bioactive oligomers with high fidelity and operational robustness.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 84.86
LogP 3.1809
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 8

Other Classifications

Building Blocks Functional Group Ether

Building Blocks Functional Group Olefins

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Serine and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Ser(Allyl)-OH

CAS No. 2381970-72-3

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