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CS-W001157 4
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5-Fluoro-2-hydroxy-3-methylbenzaldehyde

  • CAS No. 704884-74-2

  • Cat. No. CS-0103341
  • Purity≥95%
  • MDL No.MFCD04039244

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-hydroxy-3-methylbenzaldehyde|CS-0103341

Structure of 704884-74-2

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General Information

  • CAS No. 704884-74-2
  • Cat. No. CS-0103341
  • Purity ≥95%
  • MDL No. MFCD04039244
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₂
  • Molecular Weight 154.14
  • Synonym(s) None
  • SMILES O=CC1=CC(F)=CC(C)=C1O

Description

5-Fluoro-2-hydroxy-3-methylbenzaldehyde features a trifunctional aromatic core with fluorine, hydroxyl, and methyl substituents positioned for orthogonal reactivity. The electron-deficient aryl ring pairs with the aldehyde handle to enable efficient coupling in Suzuki-Miyaura and Ullmann-type transformations. This bench-stable scaffold integrates readily into complex heterocyclic systems and serves as a key intermediate in medicinal chemistry campaigns targeting kinase inhibitors and bioactive scaffolds.

Application

5-Fluoro-2-hydroxy-3-methylbenzaldehyde serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its ortho-hydroxy and meta-fluoro substituents enable directed metalation and selective functionalization, while the aldehyde group supports efficient imine formation and reductive amination. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic sequences in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H317-H318-H335
Precautionary Statements : P261-P264-P271-P272-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.65222
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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