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CS-W001157 4
Total: USD 88.00

4-Hydroxymethylthiazole

  • CAS No. 7036-04-6

  • Cat. No. CS-W003988
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Hydroxymethylthiazole|CS-W003988

Structure of 7036-04-6

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General Information

  • CAS No. 7036-04-6
  • Cat. No. CS-W003988
  • Purity ≥96%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅NOS
  • Molecular Weight 115.15
  • Synonym(s) None
  • SMILES OCc1cscn1

Description

4-Hydroxymethylthiazole features a reactive hydroxymethyl group appended to the thiazole ring, enabling straightforward derivatization in synthetic transformations. The heterocyclic scaffold imparts enhanced solubility and stability under standard conditions, making it valuable for medicinal chemistry applications and as a building block in bioconjugation strategies.

Application

4-Hydroxymethylthiazole serves as a versatile building block in medicinal chemistry, enabling efficient access to thiazole-based pharmacophores. The hydroxymethyl group facilitates direct functionalization via oxidation, etherification, or coupling reactions, while the heterocyclic core exhibits favorable stability and solubility profiles. Its compatibility with standard synthetic protocols makes it a practical choice for scaffold diversification in API development.

Synthesis

  • Route1

    References

    • ASTRAZENECA AB; ASTRAZENECA UK LIMITED Patent: WO2005/61465 A1, 2005 ; Location in patent: Page/Page column 62 ; WO 2005/061465 A1
  • Route2

    References

    • WO2006/46031 A1, ; Page/Page column 85-86 ; WO 2006/046031 A1
  • Route3

    References

    • US6200975 B1, ; US 6200975 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.6354
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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