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CS-W001157 4
Total: USD 88.00

2-Hydroxy-4-methylbenzaldehyde

  • CAS No. 698-27-1

  • Cat. No. CS-W007888
  • Purity≥98%
  • MDL No.MFCD00799550

*For research and further manufacturing use only, not for direct human use.

2-Hydroxy-4-methylbenzaldehyde|CS-W007888

Structure of 698-27-1

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General Information

  • CAS No. 698-27-1
  • Cat. No. CS-W007888
  • Purity ≥98%
  • MDL No. MFCD00799550
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈O₂
  • Molecular Weight 136.15
  • Synonym(s) None
  • SMILES O=CC1=CC=C(C)C=C1O

Description

2-Hydroxy-4-methylbenzaldehyde features a phenolic hydroxyl group adjacent to an aldehyde, enabling direct participation in electrophilic and condensation reactions. The para-methyl substituent enhances electron density at the aromatic ring, improving reactivity in coupling processes. This bench-stable compound serves as a key intermediate for bioactive heterocycles and functionalized polymers.

Application

2-Hydroxy-4-methylbenzaldehyde serves as a versatile building block in synthetic organic chemistry, enabling efficient access to substituted phenolic scaffolds and heterocycles. Its ortho-hydroxyl and para-methyl groups provide complementary reactivity for electrophilic substitution, condensation reactions, and metal-catalyzed couplings. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in medicinal chemistry and materials development.

Synthesis

  • Route1

    References

    • J. roy. tech. Coll., , vol. 3, p. 385
  • Route2
    • null|null
      108-39-4
    • ~10%
    • In-stock
      2-Hydroxy-4-methylbenzaldehyde|CS-W007888
      698-27-1

    References

    • Faeh, Christoph; Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Pflieger, Philippe Patent: US2007/185113 A1, 2007 ; Location in patent: Page/Page column 12 ;
  • Route3
    • null|null
      50-00-0
    • null|null
      108-39-4
    • ~96%
    • In-stock
      2-Hydroxy-4-methylbenzaldehyde|CS-W007888
      698-27-1

    References

    • Phan, Diem H. T.; Kim, Byoungmoo; Dong, Vy M. Journal of the American Chemical Society, 2009 , vol. 131, # 43 p. 15608 - 15609

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.51312
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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