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CS-W001157 4
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2-Fluoro-5-iodopyrimidine

  • CAS No. 697300-79-1

  • Cat. No. CS-0041982
  • Purity≥98%
  • MDL No.MFCD09038025

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-5-iodopyrimidine|CS-0041982

Structure of 697300-79-1

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General Information

  • CAS No. 697300-79-1
  • Cat. No. CS-0041982
  • Purity ≥98%
  • MDL No. MFCD09038025
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂FIN₂
  • Molecular Weight 223.97
  • Synonym(s) 2-Fluoro-5-iodo-pyrimidine
  • SMILES IC1=CN=C(F)N=C1

Description

2-Fluoro-5-iodopyrimidine serves as a key heterocyclic building block for medicinal chemistry and materials science. This electron-deficient pyrimidine features orthogonal reactive handles—fluorine at C2 and iodine at C5—enabling selective cross-coupling reactions under mild conditions. The molecule exhibits excellent stability and compatibility with palladium-catalyzed transformations, facilitating efficient construction of complex molecular architectures.

Application

2-Fluoro-5-iodopyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the synthesis of functionalized pyrimidine scaffolds. Its orthogonal reactivity—fluorine at C2 and iodine at C5—facilitates sequential transformations with high chemoselectivity. The compound exhibits excellent bench stability and is readily purified by column chromatography, making it ideal for scalable synthesis of kinase inhibitors and other bioactive heterocycles.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.2203
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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