H-D-Met-OMe.HCl

Name: H-D-Met-OMe.HCl
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 69630-60-0
Cat. No. CS-W015633
Purity≥95%
MDL No.MFCD00070385

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 69630-60-0

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General Information

CAS No. 69630-60-0
Cat. No. CS-W015633
Purity ≥95%
MDL No. MFCD00070385
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₄ClNO₂S
Molecular Weight 199.70
Synonym(s) None
SMILES N[C@@H](C(OC)=O)CCSC.Cl

Description

H-D-Met-OMe.HCl features a methyl ester-functionalized histidine derivative with a protonated imidazole ring, offering enhanced solubility and stability under standard bench conditions. This form facilitates direct incorporation into peptide synthesis workflows without additional activation steps.

Application

H-D-Met-OMe·HCl serves as a stable, bench-ready building block for peptide synthesis, enabling efficient incorporation of the D-methionine residue with orthogonal protection. Its methyl ester functionality supports direct derivatization and facilitates purification via standard chromatographic methods. The hydrochloride salt enhances solubility and handling in aqueous and organic media, making it well-suited for automated and manual solid-phase protocols.

Synthesis

Route1
- 67-56-1
- In-stock
  
  348-67-4
- ~88%
- In-stock
  
  69630-60-0
References
- Incerti, Matteo; Tognolini, Massimiliano; Russo, Simonetta; Pala, Daniele; Giorgio, Carmine; Hassan-Mohamed, Iftiin; Noberini, Roberta; Pasquale, Elena B.; Vicini, Paola; Piersanti, Silvia; Rivara, Silvia; Barocelli, Elisabetta; Mor, Marco; Lodola, Alessio Journal of Medicinal Chemistry, 2013 , vol. 56, # 7 p. 2936 - 2947
Route2
- In-stock
  
  348-67-4
- 77-76-9
- ~81%
- In-stock
  
  69630-60-0
References
- Patel, Dinesh V.; Young, Marian G.; Robinson, Simon P.; Hunihan, Lisa; Dean, Brenda J.; Gordon, Eric M. Journal of Medicinal Chemistry, 1996 , vol. 39, # 21 p. 4197 - 4210

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 52.32
LogP 0.6616
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 4

Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Methionine and derivatives

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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H-D-Met-OMe.HCl

CAS No. 69630-60-0

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