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Structure of 69543-98-2
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4-Bromo-6-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering a reactive bromine handle and a methyl group at the 6-position. This combination enables facile functionalization via cross-coupling reactions while maintaining structural stability under standard conditions. The electron-deficient pyrimidine ring facilitates nucleophilic substitution processes, making it valuable for constructing complex pharmacophores.
4-Bromo-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. Its bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl group enhances solubility and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows for API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: