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CS-W001157 4
Total: USD 88.00

4-Bromo-6-methylpyrimidine

  • CAS No. 69543-98-2

  • Cat. No. CS-W018676
  • Purity≥97%
  • MDL No.MFCD00234065

*For research and further manufacturing use only, not for direct human use.

4-Bromo-6-methylpyrimidine|CS-W018676

Structure of 69543-98-2

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General Information

  • CAS No. 69543-98-2
  • Cat. No. CS-W018676
  • Purity ≥97%
  • MDL No. MFCD00234065
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅BrN₂
  • Molecular Weight 173.01
  • Synonym(s) Pyrimidine, 4-bromo-6-methyl- (9CI)
  • SMILES BrC1=NC=NC(=C1)C

Description

4-Bromo-6-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, offering a reactive bromine handle and a methyl group at the 6-position. This combination enables facile functionalization via cross-coupling reactions while maintaining structural stability under standard conditions. The electron-deficient pyrimidine ring facilitates nucleophilic substitution processes, making it valuable for constructing complex pharmacophores.

Application

4-Bromo-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the construction of biaryl and heteroaryl scaffolds. Its bromine substituent provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl group enhances solubility and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows for API intermediate development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.54752
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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