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CS-W001157 4
Total: USD 88.00

Cyclopropanecarbohydrazide

  • CAS No. 6952-93-8

  • Cat. No. CS-D0255
  • Purity≥97%
  • MDL No.MFCD00045392

*For research and further manufacturing use only, not for direct human use.

Cyclopropanecarbohydrazide|CS-D0255

Structure of 6952-93-8

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General Information

  • CAS No. 6952-93-8
  • Cat. No. CS-D0255
  • Purity ≥97%
  • MDL No. MFCD00045392
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈N₂O
  • Molecular Weight 100.12
  • Synonym(s) Cyclopropanecarboxylic hydrazide
  • SMILES O=C(NN)C1CC1

Description

Cyclopropanecarbohydrazide features a strained cyclopropane ring fused to a carbohydrazide functional group, enabling unique reactivity in heterocycle synthesis. This bench-stable compound integrates readily into bioactive scaffolds and serves as a key intermediate in the development of targeted small molecules.

Application

Cyclopropanecarbohydrazide serves as a versatile building block in heterocyclic synthesis, enabling the construction of triazoles, imidazoles, and other nitrogen-rich scaffolds through condensation reactions. Its cyclopropyl ring imparts structural rigidity and enhanced metabolic stability, while the hydrazide functionality offers reliable reactivity with aldehydes, ketones, and activated carbonyls. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.

Synthesis

  • Route1
    • tert-Butyl 2-(cyclopropanecarbonyl)hydrazine-1-carboxylate|CS-0673091
      851295-78-8
    • ~%
    • In-stock
      Cyclopropanecarbohydrazide|CS-D0255
      6952-93-8

    References

    • WO2005/39569 A1, ; Page/Page column 39 ; WO 2005/039569 A1
  • Route2
    • null|null
      2868-37-3
    • ~43%
    • In-stock
      Cyclopropanecarbohydrazide|CS-D0255
      6952-93-8

    References

    • WO2005/40142 A1, ; Page/Page column 46 ; WO 2005/040142 A1
  • Route3
    • null|null
      4606-07-9
    • ~%
    • In-stock
      Cyclopropanecarbohydrazide|CS-D0255
      6952-93-8

    References

    • Journal of the American Chemical Society, , vol. 73, p. 2959

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅱ
Hazard Statements : H228-H302-H315-H319-H335
Precautionary Statements : P210-P240-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P370+P378-P501

Quality Control

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   -0.6137
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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