Lot numbers can be found on the outside label of a product:
Cyclopropanecarboxamide
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CAS No. 6228-73-5
- Cat. No. CS-W011356
- Purity≥98%
- MDL No.MFCD00013729
*For research and further manufacturing use only, not for direct human use.
Structure of 6228-73-5
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General Information
- CAS No. 6228-73-5
- Cat. No. CS-W011356
- Purity ≥98%
- MDL No. MFCD00013729
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₄H₇NO
- Molecular Weight 85.10
- Synonym(s) None
- SMILES O=C(N)C1CC1
Description
Cyclopropanecarboxamide features a strained cyclopropyl ring fused to an amide group, conferring high reactivity and unique conformational rigidity. This structural motif enables selective incorporation into bioactive molecules, particularly in medicinal chemistry scaffolds where geometric constraints enhance target binding affinity. The compound exhibits bench-stable handling under standard conditions and integrates readily into synthetic sequences requiring cyclic amides.
Application
Cyclopropanecarboxamide serves as a valuable building block in medicinal chemistry and synthetic organic chemistry, leveraging the strain-enhanced reactivity of the cyclopropyl ring. It functions as a versatile scaffold for amide bond formation and participates reliably in standard transformations such as reduction, hydrolysis, and coupling reactions. The molecule exhibits good bench stability and facilitates efficient incorporation into diverse heterocyclic systems and bioactive molecules, making it a practical choice for targeted synthesis.
Synthesis
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Route1
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4023-34-1 - ~99%
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In-stock
6228-73-5
References
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Daiichi Sankyo Company, Limited; Verma, Ashwani Kumar; Nagaswamy, Kumaragurubaran; Sharma, Lalima; Ghosh, Soma; Kale, Balkrishna Ramchandra; Mondal, Aniruddha; Srivastava, Punit Kumar; Dastidar, Sunanda Ghosh; Momin, Rijwan Jaffer; Wagh, Pradip Balu; Pansare, Sonali Nanasaheb; Markad, Pramod Raosaheb; Khairnar, Yogesh Balasaheb; Miyauchi, Rie; Murata, Takeshi; Ishizaki, Masayuki; Nagamochi, Masatoshi; Iimura, Shin Patent: US2014/155398 A1, 2014 ; Location in patent: Paragraph 0365 ;
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Route2
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64969-79-5
- ~96%
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In-stock
6228-73-5
References
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Bayer Aktiengesellschaft Patent: US5068428 A1, 1991 ;
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Route3
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5500-21-0
- ~92%
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In-stock
6228-73-5
References
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Liu, Kwang-Ting; Shih, Mei-Hsiu; Huang, Hsiau-Wen; Hu, Chia-Juei Synthesis, 1988 , # 9 p. 715 - 717
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H319
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.09
- LogP -0.1183
- H_Acceptors 1
- H_Donors 1
- Rotatable_Bonds 1
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