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CS-W001157 4
Total: USD 88.00

(4-Bromophenyl)(cyclopropyl)methanone

  • CAS No. 6952-89-2

  • Cat. No. CS-0186073
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Bromophenyl)(cyclopropyl)methanone|CS-0186073

Structure of 6952-89-2

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General Information

  • CAS No. 6952-89-2
  • Cat. No. CS-0186073
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₉BrO
  • Molecular Weight 225.08
  • Synonym(s) 4-Bromophenyl cyclopropyl ketone
  • SMILES C1CC1C(=O)C2=CC=C(C=C2)Br

Description

(4-Bromophenyl)(cyclopropyl)methanone features a brominated aromatic ring paired with a cyclopropyl ketone moiety, enabling direct incorporation into cross-coupling and heterocycle-forming reactions. This sterically constrained scaffold delivers enhanced metabolic stability and facilitates efficient derivatization in medicinal chemistry campaigns.

Application

(4-Bromophenyl)(cyclopropyl)methanone serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of biaryl and heterocyclic scaffolds. Its brominated aryl group facilitates palladium-catalyzed cross-coupling reactions, while the cyclopropyl ketone moiety offers stability and compatibility with diverse functional groups. The molecule exhibits excellent bench stability and simplifies purification, making it well-suited for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1
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      108-86-1
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      4023-34-1
    • ~%
    • In-stock
      (4-Bromophenyl)(cyclopropyl)methanone|CS-0186073
      6952-89-2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 24 p. 6629 - 6635
  • Route2

    References

    • Schliemann; Buege; Reppel Pharmazie, 1980 , vol. 35, # 3 p. 140 - 143
  • Route3
    • null|null
      108-86-1
    • ~%
    • In-stock
      (4-Bromophenyl)(cyclopropyl)methanone|CS-0186073
      6952-89-2

    References

    • Pharmazie, , vol. 35, # 3 p. 140 - 143

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   3.0418
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   2

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