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CS-W001157 4
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1-(3-Hydroxyphenyl)propan-1-one

  • CAS No. 13103-80-5

  • Cat. No. CS-W018910
  • Purity≥98%
  • MDL No.MFCD03428514

*For research and further manufacturing use only, not for direct human use.

1-(3-Hydroxyphenyl)propan-1-one|CS-W018910

Structure of 13103-80-5

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General Information

  • CAS No. 13103-80-5
  • Cat. No. CS-W018910
  • Purity ≥98%
  • MDL No. MFCD03428514
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₀O₂
  • Molecular Weight 150.17
  • Synonym(s) 3-hydroxypropiophenone
  • SMILES CCC(C1=CC=CC(O)=C1)=O

Description

1-(3-Hydroxyphenyl)propan-1-one features a phenolic hydroxyl group flanked by a conjugated carbonyl, enabling robust participation in cross-coupling and cyclization reactions. This scaffold delivers enhanced solubility in polar solvents and exhibits stability under standard bench conditions, facilitating its integration into complex molecular architectures.

Application

1-(3-Hydroxyphenyl)propan-1-one serves as a versatile building block in synthetic organic chemistry, enabling efficient construction of bioactive scaffolds. Its phenolic hydroxyl and ketone functionalities provide orthogonal reactivity for selective derivatization, including etherification, acylation, and conjugate addition. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for medicinal chemistry campaigns and process development workflows.

Synthesis

  • Route1

    References

    • SMITHKLINE BEECHAM CORPORATION Patent: WO2007/62145 A2, 2007 ; Location in patent: Page/Page column 41 ; WO 2007/062145 A2
  • Route2
    • In-stock
      3-Hydroxyacetophenone|CS-0015375
      121-71-1
    • null|null
      68-12-2
    • ~63%
    • In-stock
      1-(3-Hydroxyphenyl)propan-1-one|CS-W018910
      13103-80-5

    References

    • Li, Yang; Xue, Dong; Lu, Wei; Wang, Chao; Liu, Zhao-Tie; Xiao, Jianliang Organic Letters, 2014 , vol. 16, # 1 p. 66 - 69
  • Route3
    • null|null
      5453-62-3
    • ~%
    • In-stock
      1-(3-Hydroxyphenyl)propan-1-one|CS-W018910
      13103-80-5

    References

    • Journal of the American Chemical Society, , vol. 75, p. 1128

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9849
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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