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CS-W001157 4
Total: USD 88.00

2-(Methylthio)ethanamine hydrochloride

  • CAS No. 6950-53-4

  • Cat. No. CS-0063136
  • Purity≥97%
  • MDL No.MFCD02755761

*For research and further manufacturing use only, not for direct human use.

2-(Methylthio)ethanamine hydrochloride|CS-0063136

Structure of 6950-53-4

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General Information

  • CAS No. 6950-53-4
  • Cat. No. CS-0063136
  • Purity ≥97%
  • MDL No. MFCD02755761
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₁₀ClNS
  • Molecular Weight 127.64
  • Synonym(s) 2-(Methylsulfanyl)Ethanamine
  • SMILES CSCCN.[H]Cl

Description

2-(Methylthio)ethanamine hydrochloride features a sulfide-functionalized ethylamine backbone, offering enhanced nucleophilicity and solubility in aqueous systems. This bench-stable salt form facilitates straightforward handling and integration into synthetic workflows involving amine coupling or thioether derivatization.

Application

2-(Methylthio)ethanamine hydrochloride serves as a versatile sulfide-containing building block in medicinal chemistry and peptide modification. Its amine functionality enables straightforward derivatization, while the methylthio group provides orthogonal reactivity for selective functionalization. The hydrochloride salt enhances solubility and stability, facilitating handling and purification in standard synthetic workflows. It functions effectively in nucleophilic substitution reactions and serves as a key intermediate in the synthesis of bioactive heterocycles and thioether-linked scaffolds.

Synthesis

  • Route1
    • tert-Butyl(2-(methylthio)ethyl)carbamate|CS-0171926
      174360-08-8
    • ~%
    • In-stock
      2-(Methylthio)ethanamine hydrochloride|CS-0063136
      6950-53-4

    References

    • UCB PHARMA S.A.; ALI, Mezher, Hussein; BROWN, Julien, Alistair; DE CANDOLE, Benjamin, Charles; HUTCHINSON, Brian, Woodside; LANGHAM, Barry, John; NEUSS, Judi, Charlotte; QUINCEY, Joanna, Rachel; TREVITT, Graham, Peter Patent: WO2010/146351 A1, 2010 ; Location in patent: Page/Page column 69 ; WO 2010/146351 A1
  • Route2

    References

    • Jeon, Heung Bae; Jang, Yujin Biochemical and Biophysical Research Communications, 2010 , vol. 403, # 3-4 p. 442 - 446

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.7299
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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