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CS-W001157 4
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N,N-Dimethylpyrrolidin-3-amine

  • CAS No. 69478-75-7

  • Cat. No. CS-0022389
  • Purity≥96%
  • MDL No.MFCD01569246

*For research and further manufacturing use only, not for direct human use.

N,N-Dimethylpyrrolidin-3-amine|CS-0022389

Structure of 69478-75-7

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General Information

  • CAS No. 69478-75-7
  • Cat. No. CS-0022389
  • Purity ≥96%
  • MDL No. MFCD01569246
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₄N₂
  • Molecular Weight 114.19
  • Synonym(s) Dimethyl(pyrrolidin-3-yl)amine; 3-(Dimethylamino)pyrrolidine
  • SMILES CN(C)C1CNCC1

Description

N,N-Dimethylpyrrolidin-3-amine delivers a sterically hindered nitrogen center ideal for catalytic applications. This bench-stable amine integrates readily into transition-metal complexes, enhancing reactivity in cross-coupling and C–H functionalization processes. The dimethyl substitution stabilizes the lone pair while maintaining solubility in polar aprotic solvents.

Application

N,N-Dimethylpyrrolidin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through nucleophilic substitution and coupling reactions. Its tertiary amine functionality offers enhanced solubility and metabolic stability, while the pyrrolidine core provides conformational rigidity beneficial for target engagement. The dimethylamino group facilitates easy purification via ion-exchange chromatography and exhibits broad functional group tolerance under standard synthetic conditions, making it ideal for parallel synthesis campaigns and lead optimization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05
Signal Word : Danger
UN#: 2734
Class : 8 (3)
Packing Group : Ⅱ
Hazard Statements : H226-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P264-P280-P301+P330+P331-P304+P340-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   -0.0901
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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