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CS-W001157 4
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Methyl 4-aminothiophene-3-carboxylate

  • CAS No. 69363-85-5

  • Cat. No. CS-0150758
  • Purity≥98%
  • MDL No.MFCD00130102

*For research and further manufacturing use only, not for direct human use.

Methyl 4-aminothiophene-3-carboxylate|CS-0150758

Structure of 69363-85-5

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General Information

  • CAS No. 69363-85-5
  • Cat. No. CS-0150758
  • Purity ≥98%
  • MDL No. MFCD00130102
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂S
  • Molecular Weight 157.19
  • Synonym(s) METHYL 3-AMINOTHIOPHENE-4-CARBOXYLATE
  • SMILES COC(=O)C1=CSC=C1N

Description

Methyl 4-aminothiophene-3-carboxylate features a thiophene core with strategically positioned amino and ester functionalities, enabling integration into diverse heterocyclic scaffolds. The electron-rich thiophene ring enhances reactivity in transition-metal-catalyzed couplings, while the bench-stable amino group facilitates downstream derivatization. This compound serves as a key building block for bioactive molecule synthesis.

Application

Methyl 4-aminothiophene-3-carboxylate serves as a versatile scaffold for the synthesis of biologically relevant thiophene-based heterocycles. The amino group enables direct functionalization via coupling reactions, while the ester moiety supports selective reduction or hydrolysis to access carboxylic acid derivatives. Its stability under standard reaction conditions and compatibility with diverse transformations make it a practical building block in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • LAILA NUTRACEUTICALS Patent: US2010/68178 A1, 2010 ; Location in patent: Page/Page column 17 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H320
Precautionary Statements : P264-P305+P351+P338

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.1169
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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