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CS-W001157 4
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2-Chloro-5-(trichloromethyl)pyridine

  • CAS No. 69045-78-9

  • Cat. No. CS-0051963
  • Purity≥97%
  • MDL No.MFCD00160145

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-(trichloromethyl)pyridine|CS-0051963

Structure of 69045-78-9

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General Information

  • CAS No. 69045-78-9
  • Cat. No. CS-0051963
  • Purity ≥97%
  • MDL No. MFCD00160145
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₃Cl₄N
  • Molecular Weight 230.91
  • Synonym(s) 2-Chloro-5-Trichloromethylpyridine
  • SMILES ClC1=NC=C(C=C1)C(Cl)(Cl)Cl

Description

2-Chloro-5-(trichloromethyl)pyridine features a highly electron-deficient pyridine core stabilized by the strong inductive effect of the trichloromethyl group, enabling selective functionalization under mild conditions. This bench-stable reagent serves as a key building block for advanced heterocyclic systems and pharmaceutical intermediates.

Application

2-Chloro-5-(trichloromethyl)pyridine serves as a versatile building block in heterocyclic synthesis, enabling efficient construction of complex pyridine derivatives. Its trichloromethyl group exhibits high electrophilicity, facilitating nucleophilic substitution and functionalization under mild conditions. The molecule demonstrates robust bench stability and compatibility with diverse reaction environments, making it valuable for medicinal chemistry and process-scale applications requiring selective C–C or C–X bond formation.

Synthesis

  • Route1

    References

    • Haga, Takahiro; Fujikawa, Kan-ichi; Koyanagi, Tohru; Nakajima, Toshio; Hayashi, Kouji Heterocycles, 1984 , vol. 22, # 1 p. 117 - 124
  • Route2

    References

    • US4504665 A1, ;
  • Route3

    References

    • Asian Journal of Chemistry, , vol. 26, # 1 p. 110 - 112

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301
Precautionary Statements : P264-P270-P330-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   3.5617
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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