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CS-W001157 4
Total: USD 88.00

N,N'-Dimorpholine Disulfide

  • CAS No. 103-34-4

  • Cat. No. CS-0196466
  • Purity≥95%
  • MDL No.MFCD00023319

*For research and further manufacturing use only, not for direct human use.

N,N'-Dimorpholine Disulfide|CS-0196466

Structure of 103-34-4

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General Information

  • CAS No. 103-34-4
  • Cat. No. CS-0196466
  • Purity ≥95%
  • MDL No. MFCD00023319
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂O₂S₂
  • Molecular Weight 236.36
  • Synonym(s) Rubber Accelerator DTDM
  • SMILES C1COCCN1SSN2CCOCC2

Description

N,N'-Dimorpholine Disulfide serves as a stable, moisture-tolerant disulfide linker for conjugating biomolecules and functionalizing surfaces. Featuring two morpholine rings flanking a disulfide bond, it enables efficient thiol-disulfide exchange under physiological conditions. This structure delivers robust reactivity with cysteine residues while maintaining shelf stability and ease of handling in aqueous environments.

Application

N,N'-Dimorpholine Disulfide serves as a stable, bench-ready oxidizing agent for the formation of disulfide bonds in peptide and protein synthesis. It facilitates selective cysteine oxidation under mild conditions, offering excellent functional group tolerance and ease of purification. Its morpholine-based structure enhances solubility in polar solvents, enabling efficient coupling in aqueous-organic mixtures. This reagent is particularly valuable for constructing cystine bridges in complex biomolecules with high reproducibility.

Synthesis

  • Route1
    • null|null
      110-91-8
    • ~82%
    • In-stock
      N,N'-Dimorpholine Disulfide|CS-0196466
      103-34-4

    References

    • Sun, Ranfeng; Zhang, Yonglin; Chen, Li; Li, Yongqiang; Li, Qingshan; Song, Haibin; Huang, Runqiu; Bi, Fuchun; Wang, Qingmin Journal of Agricultural and Food Chemistry, 2009 , vol. 57, # 9 p. 3661 - 3668
  • Route2
    • null|null
      139558-39-7
    • ~74%
    • In-stock
      N,N'-Dimorpholine Disulfide|CS-0196466
      103-34-4

    References

    • Shermolovich, Yu. G.; Solov'ev, A. V.; Borodin, A. V.; Pen'kovskii, V. V.; Trachevskii, V. V.; Markovskii, L. N. Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 8.1 p. 1433 - 1436 Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 8 p. 1637 - 1641
  • Route3
    • null|null
      5038-11-9
    • ~6%
    • null|null
      16131-52-5
    • In-stock
      N,N'-Dimorpholine Disulfide|CS-0196466
      103-34-4
    • null|null
      16131-53-6

    References

    • Synthetic Communications, , vol. 10, # 4 p. 291 - 298

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H317-H335-H401-H411
Precautionary Statements : P261-P271-P272-P273-P280-P302+P352-P363-P391-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.94
  • LogP   0.8622
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   3

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