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Structure of 69034-08-8
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5-(Trifluoromethyl)pyrimidin-2-amine features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability. This pyrimidine scaffold integrates readily into kinase inhibitors and pharmaceutical intermediates, offering improved solubility and bioavailability. The amine functionality enables efficient coupling reactions under standard conditions.
5-(Trifluoromethyl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the pyrimidine amine functionality facilitates derivatization via Suzuki-Miyaura, Buchwald-Hartwig, or reductive amination protocols. The compound exhibits excellent bench stability and is compatible with diverse functional groups, supporting efficient route development for pharmaceutical intermediates and agrochemical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: