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CS-W001157 4
Total: USD 88.00

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine

  • CAS No. 1201657-24-0

  • Cat. No. CS-0050923
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine|CS-0050923

Structure of 1201657-24-0

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General Information

  • CAS No. 1201657-24-0
  • Cat. No. CS-0050923
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClF₃N₃
  • Molecular Weight 197.55
  • Synonym(s) None
  • SMILES NC1=NC=C(C(Cl)=N1)C(F)(F)F

Description

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine features a trifluoromethyl group that enhances metabolic stability and lipophilicity, while the chloro substituent enables facile cross-coupling. This electron-deficient pyrimidine scaffold integrates readily into pharmaceutical intermediates, particularly in kinase inhibitor development and agrochemical design.

Application

4-Chloro-5-(trifluoromethyl)pyrimidin-2-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds through palladium-catalyzed cross-coupling reactions. Its chloro group facilitates reliable C–C and C–N bond formation, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity. The amine functionality offers direct access to diverse analogs via acylation, alkylation, or further functionalization, making it ideal for rapid lead optimization in drug discovery programs.

Safety Information

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GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   51.8
  • LogP   1.731
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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