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CS-W001157 4
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2-(Piperidin-4-yl)thiazole hydrochloride

  • CAS No. 690262-03-4

  • Cat. No. CS-0265774
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Piperidin-4-yl)thiazole hydrochloride|CS-0265774

Structure of 690262-03-4

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General Information

  • CAS No. 690262-03-4
  • Cat. No. CS-0265774
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₃ClN₂S
  • Molecular Weight 204.72
  • Synonym(s) None
  • SMILES [H]Cl.C1(C2=NC=CS2)CCNCC1

Description

2-(Piperidin-4-yl)thiazole hydrochloride features a rigid thiazole core linked to a piperidine moiety, delivering enhanced solubility and metabolic stability. This scaffold integrates well into medicinal chemistry campaigns targeting kinase inhibition and CNS-penetrant therapeutics. The hydrochloride salt ensures improved crystallinity and handling under standard bench conditions.

Application

2-(Piperidin-4-yl)thiazole hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of thiazole-containing scaffolds prevalent in kinase inhibitors and CNS-targeted therapeutics. The piperidine moiety offers favorable solubility and metabolic stability, while the thiazole ring provides a rigid, planar heterocyclic core amenable to further functionalization. Its hydrochloride salt enhances crystallinity and shelf stability, facilitating handling and purification in high-throughput synthesis workflows.

Safety Information

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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   24.92
  • LogP   2.0319
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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