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CS-W001157 4
Total: USD 88.00

iBu-dG

  • CAS No. 68892-42-2

  • Cat. No. CS-W016727
  • Purity≥97%
  • MDL No.MFCD00010060

*For research and further manufacturing use only, not for direct human use.

iBu-dG|CS-W016727

Structure of 68892-42-2

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General Information

  • CAS No. 68892-42-2
  • Cat. No. CS-W016727
  • Purity ≥97%
  • MDL No. MFCD00010060
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₉N₅O₅
  • Molecular Weight 337.34
  • Synonym(s) N2-Isobutyryl-2'-deoxyguanosine
  • SMILES OC[C@H]([C@@H](O)C1)O[C@H]1N2C(N=C(NC(C(C)C)=O)N=C3O)=C3N=C2

Description

iBu-dG features a tert-butyl group appended to the deoxyguanosine scaffold, enhancing stability and facilitating purification in oligonucleotide synthesis. This modified nucleoside integrates seamlessly into DNA strands under standard conditions, offering improved handling and reduced side reactions during solid-phase assembly.

Synthesis

  • Route1
    • null|null
      97-72-3
    • In-stock
      2'-Deoxyguanosine|CS-3151
      961-07-9
    • ~82%
    • In-stock
      iBu-dG|CS-W016727
      68892-42-2

    References

    • Challa, Hemavathi; Bruice, Thomas C. Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 6 p. 1475 - 1481
  • Route2

    References

    • Wahlstrom, Jan L.; Ronald, Robert C. Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6021 - 6022
  • Route3

    References

    • Glaser, Gad; Katzhendler, Jehoshua; Hilgenfeld, Rolf; Vidavski, Roee; Wexselblatt, Ezequiel; Prez-Menahemov, Tamar; Kaspy, Ilana Patent: US2011/86813 A1, 2011 ; Location in patent: Page/Page column 33-34 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P340-P362-P403-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   142.62
  • LogP   -0.2329
  • H_Acceptors   9
  • H_Donors   4
  • Rotatable_Bonds   4

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