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CS-W001157 4
Total: USD 88.00

iBu-rG

  • CAS No. 64350-24-9

  • Cat. No. CS-0046499
  • Purity≥97%
  • MDL No.MFCD00274102

*For research and further manufacturing use only, not for direct human use.

iBu-rG|CS-0046499

Structure of 64350-24-9

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General Information

  • CAS No. 64350-24-9
  • Cat. No. CS-0046499
  • Purity ≥97%
  • MDL No. MFCD00274102
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₉N₅O₆
  • Molecular Weight 353.33
  • Synonym(s) N-Isobutyrylguanosine
  • SMILES O[C@H]1[C@@H](O)[C@H](N2C(N=C(NC(C(C)C)=O)NC3=O)=C3N=C2)O[C@@H]1CO

Description

iBu-rG is a bench-stable, moisture-tolerant building block featuring a tert-butyl-protected guanidine moiety. This robust scaffold integrates readily into peptide backbones and enables efficient access to bioactive analogs under standard coupling conditions.

Synthesis

  • Route1
    • null|null
      79-30-1
    • In-stock
      Guanosine|CS-W020018
      118-00-3
    • ~84%
    • In-stock
      iBu-rG|CS-0046499
      64350-24-9

    References

    • Vertuani, Silvia; Baldisserotto, Anna; Varani, Katia; Borea, Pier Andrea; De Marcos Maria Cruz, Bonache; Ferraro, Luca; Manfredini, Stefano; Dalpiaz, Alessandro European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 202 - 209
  • Route2
    • null|null
      97-72-3
    • ~38%
    • In-stock
      iBu-rG|CS-0046499
      64350-24-9

    References

    • Japan Science and Technology Agency Patent: EP1604995 A1, 2005 ; Location in patent: Page/Page column 5 ;
  • Route3
    • null|null
      97-72-3
    • In-stock
      Guanosine|CS-W020018
      118-00-3
    • ~39%
    • In-stock
      iBu-rG|CS-0046499
      64350-24-9

    References

    • Xu, Yan; Ikeda, Reiko; Sugiyama, Hiroshi Journal of the American Chemical Society, 2003 , vol. 125, # 44 p. 13519 - 13524

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   162.59
  • LogP   -1.6744
  • H_Acceptors   9
  • H_Donors   5
  • Rotatable_Bonds   4

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