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CS-W001157 4
Total: USD 88.00

2-Fluoro-4-hydroxyphenylacetic acid

  • CAS No. 68886-07-7

  • Cat. No. CS-W021691
  • Molecule weightNone
  • Purity≥96%
  • MDL No.MFCD09027748

*For research and further manufacturing use only, not for direct human use.

2-Fluoro-4-hydroxyphenylacetic acid|CS-W021691

Structure of 68886-07-7

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General Information

  • CAS No. 68886-07-7
  • Cat. No. CS-W021691
  • Purity ≥96%
  • MDL No. MFCD09027748
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇FO₃
  • Molecular Weight None
  • Synonym(s) (2-Fluoro-4-hydroxyphenyl)acetic acid
  • SMILES FC1=C(C=CC(=C1)O)CC(=O)O

Description

2-Fluoro-4-hydroxyphenylacetic acid features a strategically positioned fluorine atom and hydroxyl group on the aromatic ring, enabling enhanced metabolic stability and targeted hydrogen bonding. This configuration supports efficient incorporation into bioactive scaffolds for medicinal chemistry applications.

Application

2-Fluoro-4-hydroxyphenylacetic acid serves as a versatile building block for the synthesis of bioactive arylacetic acid derivatives. Its ortho-fluoro and para-hydroxy functionalities enable directed metalation, facilitate coupling reactions, and support hydrogen bonding in target molecules. The compound exhibits good bench stability, mild purification requirements, and compatibility with standard functional group manipulations, making it well-suited for medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • WO2010/4347 A1, ; Page/Page column 30 ; WO 2010/004347 A1
  • Route2
    • 2-(2-Fluoro-4-hydroxyphenyl)-2-hydroxyacetic acid|CS-1162943
      78989-55-6
    • ~%
    • In-stock
      2-Fluoro-4-hydroxyphenylacetic acid|CS-W021691
      68886-07-7

    References

    • Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, , vol. 237, p. 399 - 406
  • Route3

    References

    • Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, , vol. 237, p. 399 - 406

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   1.1584
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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