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CS-W001157 4
Total: USD 88.00

Glycyl-D-leucine

  • CAS No. 688-13-1

  • Cat. No. CS-0119991
  • Purity≥97%
  • MDL No.MFCD00066050

*For research and further manufacturing use only, not for direct human use.

Glycyl-D-leucine|CS-0119991

Structure of 688-13-1

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General Information

  • CAS No. 688-13-1
  • Cat. No. CS-0119991
  • Purity ≥97%
  • MDL No. MFCD00066050
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₆N₂O₃
  • Molecular Weight 188.22
  • Synonym(s) H-Gly-D-Leu-OH
  • SMILES CC(C)C[C@H](C(O)=O)NC(CN)=O

Description

Glycyl-D-leucine is a dipeptide featuring a D-leucine residue linked to glycine via a stable amide bond. This configuration imparts enhanced metabolic stability and resistance to proteolytic degradation, making it valuable for peptide-based drug design and synthetic intermediates in bioactive molecule development.

Application

Glycyl-D-leucine serves as a stable, bench-ready dipeptide building block for peptide synthesis, offering predictable coupling efficiency and orthogonal protection compatibility. Its D-leucine residue provides steric hindrance and metabolic stability, making it valuable in designing bioactive peptides and peptidomimetics with enhanced proteolytic resistance.

Synthesis

  • Route1

    References

    • Journal of the American Chemical Society, , vol. 63, p. 2605
  • Route2
    • ((Benzyloxy)carbonyl)glycyl-D-leucine|CS-0511707
      57818-73-2
    • ~%
    • In-stock
      Glycyl-D-leucine|CS-0119991
      688-13-1

    References

    • Journal of the American Chemical Society, , vol. 63, p. 2605
  • Route3
    • Methyl D-leucinate|CS-0093752
      23032-21-5
    • ~%
    • In-stock
      Glycyl-D-leucine|CS-0119991
      688-13-1

    References

    • Journal of the American Chemical Society, , vol. 63, p. 2605

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   92.42
  • LogP   -0.4394
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   5

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