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CS-W001157 4
Total: USD 88.00

Boc-2-Abz-OH

  • CAS No. 68790-38-5

  • Cat. No. CS-W010311
  • Purity≥98%
  • MDL No.MFCD00151862

*For research and further manufacturing use only, not for direct human use.

Boc-2-Abz-OH|CS-W010311

Structure of 68790-38-5

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General Information

  • CAS No. 68790-38-5
  • Cat. No. CS-W010311
  • Purity ≥98%
  • MDL No. MFCD00151862
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₄
  • Molecular Weight 237.25
  • Synonym(s) 2-[(tert-butoxycarbonyl)amino]benzoato
  • SMILES O=C(O)C1=CC=CC=C1NC(OC(C)(C)C)=O

Description

Boc-2-Abz-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a Boc-protected α-amino group and a para-aminobenzoyl (Abz) side chain. This combination enables direct incorporation into peptide sequences without additional protection steps, streamlining synthesis of fluorescent or labeled peptides.

Application

Boc-2-Abz-OH serves as a versatile building block for peptide and peptidomimetic synthesis, enabling efficient incorporation of the 2-aminobenzoic acid (2-Abz) moiety. Its tert-butoxycarbonyl (Boc) group provides robust protection of the amine, offering excellent stability under basic conditions and facilitating straightforward deprotection during late-stage functionalization. The ortho-amino functionality enables direct coupling in standard solid-phase and solution-phase workflows, supporting diverse conjugation strategies in medicinal chemistry and bioconjugation applications.

Synthesis

  • Route1
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      118-92-3
    • ~94%
    • In-stock
      Boc-2-Abz-OH|CS-W010311
      68790-38-5

    References

    • Siddaiah; Basha; Padma Rao; Viplava Prasad; Suryachendra Rao Chemistry Letters, 2010 , vol. 39, # 11 p. 1127 - 1129
  • Route2
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • 2-Hydrazinylbenzoic acid|CS-0666897
      5326-27-2
    • ~79%
    • In-stock
      Boc-2-Abz-OH|CS-W010311
      68790-38-5

    References

    • Chandrasekhar; Raji Reddy; Jagadeeshwar Rao Synlett, 2001 , # 10 p. 1561 - 1562
  • Route3
    • In-stock
      Di-tert-butyl dicarbonate|CS-0017817
      24424-99-5
    • null|null
      635-54-1
    • ~77%
    • In-stock
      Boc-2-Abz-OH|CS-W010311
      68790-38-5

    References

    • Chandrasekhar; Raji Reddy; Jagadeeshwar Rao Synlett, 2001 , # 10 p. 1561 - 1562

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.7318
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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