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CS-W001157 4
Total: USD 88.00

4-(Trifluoromethyl)-1-indanone

  • CAS No. 68755-42-0

  • Cat. No. CS-B1062
  • Purity≥95%
  • MDL No.MFCD07772121

*For research and further manufacturing use only, not for direct human use.

4-(Trifluoromethyl)-1-indanone|CS-B1062

Structure of 68755-42-0

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General Information

  • CAS No. 68755-42-0
  • Cat. No. CS-B1062
  • Purity ≥95%
  • MDL No. MFCD07772121
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇F₃O
  • Molecular Weight 200.16
  • Synonym(s) 4-TrifluoroMethyl-indan-1-one
  • SMILES O=C1CCC2=C(C(F)(F)F)C=CC=C21

Description

4-(Trifluoromethyl)-1-indanone features a trifluoromethyl group at the 4-position of an indanone scaffold, imparting strong electron-withdrawing character and enhanced metabolic stability. This configuration supports its utility in medicinal chemistry for modulating pharmacokinetic properties. The compound serves as a key intermediate in synthesizing bioactive molecules and functional materials.

Application

4-(Trifluoromethyl)-1-indanone serves as a valuable building block in medicinal chemistry, enabling the synthesis of bioactive indanone derivatives through standard functional group transformations. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the ketone functionality supports nucleophilic additions, reductive amination, and transition-metal-catalyzed couplings. Bench-stable and amenable to purification via recrystallization, it functions reliably in multi-step syntheses of pharmaceutical intermediates and heterocyclic scaffolds.

Synthesis

  • Route1
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      201230-82-2
    • null|null
      40230-94-2
    • ~%
    • In-stock
      4-(Trifluoromethyl)-1-indanone|CS-B1062
      68755-42-0

    References

    • Journal of Medicinal Chemistry, , vol. 51, # 3 p. 392 - 395

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   2.8343
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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