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CS-W001157 4
Total: USD 88.00

(1R,2R)-2-aminocyclopentanol hydrochloride

  • CAS No. 68327-11-7

  • Cat. No. CS-W008557
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1R,2R)-2-aminocyclopentanol hydrochloride|CS-W008557

Structure of 68327-11-7

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General Information

  • CAS No. 68327-11-7
  • Cat. No. CS-W008557
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂ClNO
  • Molecular Weight 137.61
  • Synonym(s) trans-2-Aminocyclopentanol hydrochloride
  • SMILES N[C@@H]1CCC[C@H]1O.Cl

Description

This chiral amino alcohol delivers a stereochemically defined scaffold for asymmetric synthesis, featuring a bench-stable hydrochloride salt form and a rigid cyclopentane ring that enforces conformational control. The primary amine and adjacent hydroxyl group enable direct functionalization in catalytic transformations and ligand development.

Application

(1R,2R)-2-Aminocyclopentanol hydrochloride serves as a stereochemically defined chiral building block for the synthesis of bioactive heterocycles and medicinal intermediates. Its bench-stable hydrochloride salt form enables straightforward handling and purification, while the adjacent amine and alcohol functionalities offer orthogonal reactivity for derivatization in multistep sequences. This compound facilitates efficient access to cyclopentane-based scaffolds commonly found in pharmaceuticals and agrochemicals.

Synthesis

  • Route1
    • Benzyl ((1R,2R)-2-hydroxycyclopentyl)carbamate|CS-0374332
      672310-36-0
    • ~78%
    • In-stock
      (1R,2R)-2-aminocyclopentanol hydrochloride|CS-W008557
      68327-11-7

    References

    • Takasago International Corporation Patent: EP1398310 A1, 2004 ; Location in patent: Page 17 ;
  • Route2
    • (1S,2S)-2-Aminocyclopentanol|CS-0054084
      930-45-0
    • ~%
    • In-stock
      (1R,2R)-2-aminocyclopentanol hydrochloride|CS-W008557
      68327-11-7

    References

    • Birrell, James A.; Jacobsen, Eric N. Organic Letters, 2013 , vol. 15, # 12 p. 2895 - 2897
  • Route3
    • null|null
      285-67-6
    • ~%
    • In-stock
      (1R,2R)-2-aminocyclopentanol hydrochloride|CS-W008557
      68327-11-7

    References

    • Organic Letters, , vol. 15, # 12 p. 2895 - 2897

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   0.2803
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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