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Structure of 681249-57-0
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This tetrahydrotriazolopyrazine features a trifluoromethyl group that imparts enhanced electron-withdrawing character and metabolic stability. The saturated ring system ensures improved solubility and compatibility in synthetic transformations. This scaffold serves as a privileged core in bioactive molecule design, particularly for kinase inhibitors and CNS-targeted therapeutics.
2-(Trifluoromethyl)-5,6,7,8-tetrahydro[1,2,4]triazolo[1,5-a]pyrazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to complex nitrogen-rich scaffolds. Its trifluoromethyl group enhances metabolic stability and modulates lipophilicity, while the saturated triazolopyrazine core offers favorable functional group tolerance and compatibility with standard coupling reactions. The compound demonstrates bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns and lead optimization workflows.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: