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CS-W001157 4
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5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine

  • CAS No. 233278-56-3

  • Cat. No. CS-W005233
  • Purity≥97%
  • MDL No.MFCD09835083

*For research and further manufacturing use only, not for direct human use.

5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine|CS-W005233

Structure of 233278-56-3

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General Information

  • CAS No. 233278-56-3
  • Cat. No. CS-W005233
  • Purity ≥97%
  • MDL No. MFCD09835083
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₈N₄
  • Molecular Weight 124.14
  • Synonym(s) 5,6,7,8-Tetrahydro-[1,2,4]triazolo[1,5-a]pyrazine
  • SMILES N1=C2[N](N=C1)CCNC2

Description

5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine is a saturated heterocyclic scaffold featuring fused triazolopyrazine core with enhanced stability and tunable basicity. This rigid, electron-rich framework integrates readily into medicinal chemistry libraries, serving as a key pharmacophore in kinase inhibitor design. Its bench-stable nature enables straightforward handling under standard conditions.

Application

5,6,7,8-Tetrahydro[1,2,4]triazolo[1,5-a]pyrazine serves as a versatile heterocyclic scaffold enabling efficient access to bioactive molecules through established coupling and functionalization protocols. Its stable, saturated core exhibits excellent bench handling, broad functional group tolerance, and compatibility with standard synthetic transformations, making it a practical building block for medicinal chemistry campaigns and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   42.74
  • LogP   -0.6187
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   0

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