(4R)-1-Boc-4-fluoro-D-proline

Name: (4R)-1-Boc-4-fluoro-D-proline
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 681128-51-8
Cat. No. CS-0053468
Molecule weightNone
Purity≥95%
MDL No.MFCD02684479

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(4R)-1-Boc-4-fluoro-D-proline|CS-0053468

Structure of 681128-51-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 681128-51-8
Cat. No. CS-0053468
Purity ≥95%
MDL No. MFCD02684479
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₆FNO₄
Molecular Weight None
Synonym(s) (2R,4R)-1-(tert-Butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid
SMILES CC(C)(C)OC(=O)N1C[C@H](F)C[C@@H]1C(O)=O

Description

(4R)-1-Boc-4-fluoro-D-proline is a stereochemically defined, bench-stable proline derivative featuring a fluorinated C4 position and a Boc-protected nitrogen. This configuration enables direct incorporation into peptide sequences where conformational rigidity and enhanced metabolic stability are required. The fluorine atom imparts unique electronic effects that modulate backbone geometry and hydrogen bonding potential.

Application

(4R)-1-Boc-4-fluoro-D-proline serves as a conformationally constrained, stereochemically defined building block for the synthesis of bioactive peptides and heterocyclic scaffolds. The Boc group provides stable protection under standard peptide coupling conditions, while the 4-fluoro substituent enhances backbone rigidity and modulates electronic properties. It functions effectively in solution-phase and solid-phase synthesis, enabling efficient incorporation into peptidomimetics with improved metabolic stability and target affinity.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 66.84
LogP 1.4185
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science Amino Acids and their Derivatives Proline and derivatives

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

(4R)-1-Boc-4-fluoro-D-proline sigma(4R)-1-Boc-4-fluoro-D-proline manufacturer(4R)-1-Boc-4-fluoro-D-proline price(4R)-1-Boc-4-fluoro-D-proline structure(4R)-1-Boc-4-fluoro-D-proline SDSbuy (4R)-1-Boc-4-fluoro-D-proline(4R)-1-Boc-4-fluoro-D-proline supplier(4R)-1-Boc-4-fluoro-D-proline uses(4R)-1-Boc-4-fluoro-D-proline molecular weightprice of (4R)-1-Boc-4-fluoro-D-proline(4R)-1-Boc-4-fluoro-D-proline chemical name formula of (4R)-1-Boc-4-fluoro-D-proline

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

(4R)-1-Boc-4-fluoro-D-proline

CAS No. 681128-51-8

Recommended Products