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Structure of 681128-50-7
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(4S)-1-Boc-4-fluoro-D-proline features a stereochemically defined fluorinated proline scaffold with enhanced conformational rigidity. The Boc group enables straightforward protection during peptide synthesis, while the fluorine atom imparts favorable electronic and metabolic stability. This derivative integrates efficiently into peptidomimetics and bioactive oligomers under standard coupling conditions.
(4S)-1-Boc-4-fluoro-D-proline serves as a conformationally constrained, fluorinated proline surrogate in peptide synthesis, enabling precise control over backbone dihedral angles. Its Boc group provides excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The 4-fluoro substitution enhances both metabolic stability and electronic modulation of amide bond geometry, making it particularly valuable for constructing bioactive peptides and peptidomimetics with improved pharmacokinetic profiles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: