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CS-W001157 4
Total: USD 88.00

1,7-Naphthyridin-8(7H)-one

  • CAS No. 67967-11-7

  • Cat. No. CS-W006725
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,7-Naphthyridin-8(7H)-one|CS-W006725

Structure of 67967-11-7

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General Information

  • CAS No. 67967-11-7
  • Cat. No. CS-W006725
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) 7H-1,7-NAPHTHYRIDIN-8-ONE
  • SMILES O=C1NC=CC2=C1N=CC=C2

Description

1,7-Naphthyridin-8(7H)-one features a fused bicyclic core with nitrogen atoms at strategic positions, enabling strong hydrogen bonding and enhanced solubility in polar solvents. This scaffold integrates readily into medicinal chemistry libraries due to its planar geometry and ability to engage in directional intermolecular interactions.

Application

1,7-Naphthyridin-8(7H)-one serves as a versatile heterocyclic scaffold in medicinal chemistry, enabling efficient access to nitrogen-containing biaryls and fused ring systems. Its amphoteric nature facilitates metal-catalyzed cross-coupling reactions and functionalization at C3 and C4 positions. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it a practical building block for lead optimization campaigns involving kinase inhibitors and DNA-targeting agents.

Synthesis

  • Route1
    • null|null
      97308-57-1
    • ~74%
    • In-stock
      1,7-Naphthyridin-8(7H)-one|CS-W006725
      67967-11-7

    References

    • Sakamoto, Takao; Kondo, Yoshinori; Yamanaka, Hiroshi Chemical & Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 626 - 633
  • Route2

    References

    • Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633
  • Route3
    • 3-((Trimethylsilyl)ethynyl)picolinonitrile|CS-1717360
      97308-50-4
    • ~%
    • In-stock
      1,7-Naphthyridin-8(7H)-one|CS-W006725
      67967-11-7

    References

    • Chemical & Pharmaceutical Bulletin, , vol. 33, # 2 p. 626 - 633

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   45.75
  • LogP   0.9231
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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